Super-orthologsĀ 


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Orthology is defined as two genes whose most recent common ancestor represents a speciation event. The term super-orthology is a more restrictive definition, and comes from Zmasek and Eddy BMC Bioinformatics, 2002: for two genes to be super-orthologs, the path in the phylogenetic tree joining the two must pass only through nodes representing speciation. If two genes are super-orthologs, they are more likely to share a common function than if they are orthologs but not super-orthologs, since gene duplication events are disallowed on the evolutionary path between the two genes. (http://phylofacts.berkeley.edu/orthologs/faq/)